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Compound Detail

CHEMBL2113529

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CCCCCCc1nc(N)c2ncn([C@@H]3O[C@H](C(=O)NCC)[C@@H](O)[C@H]3O)c2n1

Basic Information

ChEMBL ID CHEMBL2113529
Phase Preclinical
Structure Type MOL
InChI Key HXBNUMFVVMKQDN-MOROJQBDSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

392.5
MW (Da)
0.29
ALogP
9
HBA
4
HBD
148.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H28N6O4
MW 392.46
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness 0.13

Activity Summary

EC50 1 meas. best 9.0
Ki 1 meas. best 6.87

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
EC50 9.0 9.0 1.0 1
Adenosine receptor A2a
CHEMBL302
Ki 6.87 6.87 136.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8863798 10.1021/jm960376g Adenosine receptor A2a 3
8863798 10.1021/jm960376g Adenosine receptor A1 2
8863798 10.1021/jm960376g Adenosine receptors; A1 & A2a 1

Data from ChEMBL 36 via Core Engine