Compound Detail
CHEMBL212233
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Basic Information
| ChEMBL ID | CHEMBL212233 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZALHFQNLXQORTH-FGLATXDZSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
272.2
MW (Da)
-1.91
ALogP
5
HBA
4
HBD
158.2
PSA (Ų)
0.43
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 4.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 4.32 | 4.32 | 48300.0 | 1 |
| Metabotropic glutamate receptor 8 CHEMBL2718 | EC50 | 4.25 | 4.25 | 56200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 48300.0 | nM | 4.32 | Activity at rat mGluR4 receptor measured as intracellular calcium concentration ... | 16828551 |
| Metabotropic glutamate receptor 8 | EC50 | = | 56200.0 | nM | 4.25 | Activity at rat mGluR8 receptor measured as intracellular calcium concentration ... | 16828551 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 4 | 4 |
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 8 | 3 |
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 3 | 1 |
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 1 | 1 |
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 2 | 1 |
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 5 | 1 |
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 6 | 1 |
| 16828551 | 10.1016/j.bmcl.2006.06.062 | Metabotropic glutamate receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine