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Compound Detail

CHEMBL2135460

TERLIPRESSIN
💊 Approved Drug
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💊 Approved Drug
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2135460
Name TERLIPRESSIN
Phase Approved
Structure Type BOTH
InChI Key BENFXAYNYRLAIU-QSVFAHTRSA-N
Therapeutic ✓ Yes
Active Moiety CHEMBL1200690

Known Names

Glycylpressin Glypressin Terlipresina Terlipressin Terlipressin acetate Terlipressine Terlivaz Variquel
0
Targets
0
Activities
0
Assay Types
1
PK Parameters
20
Publications
8
Known Names
8
Indications
2
Mechanisms

Molecular Properties

1227.4
MW (Da)

Drug Information

Molecule Type Protein
First Approval 2022
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Parenteral

Flags

Black Box Warning Natural Product First in Class Prodrug
USAN Stem -pressin
USAN Year 2006

Extended Properties

Molecular Formula C52H74N16O15S2
MW 1227.40

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Vasopressin V1 receptor binding agent BINDING AGENT Vasopressin V1 receptor ✓ ✓
Vasopressin V2 receptor binding agent BINDING AGENT Vasopressin V2 receptor ✓ ✓

Indications

Hepatorenal Syndrome Renal Insufficiency Renal Insufficiency Hemoptysis Hemorrhage Liver Cirrhosis Liver Failure Shock, Septic

ATC Classification

H01BA04
terlipressin
Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Level 2: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES

Pharmacokinetic Data

Parameter Value Units Species
T1/2 0.9 hr Homo sapiens

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 3
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 1
38691890 10.1016/j.ejmech.2024.116456 ADMET 1
37468498 10.1038/s41467-023-40064-9 Kappa-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Neuronal acetylcholine receptor subunit alpha-4 1
37468498 10.1038/s41467-023-40064-9 Beta-1 adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Glutamate receptor ionotropic, NMDA 1 1
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine