Compound Detail
CHEMBL213992
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Basic Information
| ChEMBL ID | CHEMBL213992 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FQOBLOHRHRCTMT-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
436.7
MW (Da)
3.96
ALogP
5
HBA
3
HBD
83.5
PSA (Ų)
0.38
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase 1 CHEMBL3587 | IC50 | 7.38 | 7.38 | 42.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | = | 42.0 | nM | 7.38 | Inhibition of MEK1 | 16725322 |
| Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | = | 42.0 | nM | 7.38 | Inhibition of MEK-1 activity | 16934458 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16934458 | 10.1016/j.bmcl.2006.08.048 | Dual specificity mitogen-activated protein kinase kinase 1 | 2 |
| 16725322 | 10.1016/j.bmcl.2006.05.019 | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine