Compound Detail
CHEMBL214834
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Basic Information
| ChEMBL ID | CHEMBL214834 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IEKNNRQNPQYALN-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
353.4
MW (Da)
5.30
ALogP
3
HBA
1
HBD
61.1
PSA (Ų)
0.80
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 2 CHEMBL4016 | EC50 | 7.11 | 6.875 | 78.0 | 2 |
| Glutamate receptor 4 CHEMBL3190 | EC50 | 6.56 | 6.435 | 273.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 2 | EC50 | = | 78.0 | nM | 7.11 | Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamat... | 16879964 |
| Glutamate receptor 2 | EC50 | = | 231.0 | nM | 6.64 | Activity against human GLUR2 flop expressed in HEK293 cells assessed as glutamat... | 16879964 |
| Glutamate receptor 4 | EC50 | = | 273.0 | nM | 6.56 | Activity against human GLUR4 flip expressed in HEK293 cells assessed as glutamat... | 16879964 |
| Glutamate receptor 4 | EC50 | = | 488.0 | nM | 6.31 | Activity against human GLUR4 flop expressed in HEK293 cells assessed as glutamat... | 16879964 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16879964 | 10.1016/j.bmcl.2006.07.035 | Glutamate receptor 4 | 2 |
| 16879964 | 10.1016/j.bmcl.2006.07.035 | Glutamate receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine