Compound Detail
CHEMBL215433
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Basic Information
| ChEMBL ID | CHEMBL215433 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMBHNJXBHHHZFG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
5.00
ALogP
3
HBA
2
HBD
79.3
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL5102 | IC50 | 6.25 | 6.25 | 560.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 560.0 | nM | 6.25 | Antagonist activity against low pH(5.0-5.5)-activated rat VR1 | 16870426 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16870426 | 10.1016/j.bmcl.2006.07.010 | Transient receptor potential cation channel subfamily V member 1 | 2 |
| 16870426 | 10.1016/j.bmcl.2006.07.010 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine