Compound Detail
CHEMBL2158056
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2158056 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CWXICLIHKGNHEH-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
3.33
ALogP
6
HBA
0
HBD
90.9
PSA (Ų)
0.41
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.82
IC50 1 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | EC50 | 7.82 | 7.82 | 15.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 11.0 | nM | 7.96 | Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemic... | 21456625 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | EC50 | = | 15.0 | nM | 7.82 | Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 ... | 21456625 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21456625 | 10.1021/jm200070e | 3',5'-cyclic-AMP phosphodiesterase 4A | 2 |
Data from ChEMBL 36 via Core Engine