Compound Detail
CHEMBL2158410
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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C
Basic Information
| ChEMBL ID | CHEMBL2158410 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | UKVFVQPAANCXIL-FJVFSOETSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
4169.5
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 10.05
IC50 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor CHEMBL5862 | EC50 | 10.05 | 10.05 | 0.1 | 1 |
| Glucagon-like peptide 1 receptor CHEMBL5862 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | EC50 | = | 0.09 | nM | 10.05 | Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation ... | 22103243 |
| Glucagon-like peptide 1 receptor | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 c... | 22103243 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22103243 | 10.1021/jm201150j | Glucagon-like peptide 1 receptor | 5 |
| 22103243 | 10.1021/jm201150j | Glucagon-like peptide 2 receptor | 1 |
| 27994747 | 10.1021/acsmedchemlett.6b00314 | Probable G-protein coupled receptor 142 | 1 |
Data from ChEMBL 36 via Core Engine