Compound Detail
CHEMBL2158516
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COc1cc(C2CCN(CC(N)=O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1
Basic Information
| ChEMBL ID | CHEMBL2158516 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HATRKFPXWDUKPL-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
4
PK Parameters
6
Publications
0
Known Names
Molecular Properties
563.7
MW (Da)
3.21
ALogP
9
HBA
2
HBD
135.2
PSA (Ų)
0.32
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ALK tyrosine kinase receptor CHEMBL4247 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) CHEMBL2111387 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| Insulin receptor CHEMBL1981 | IC50 | 6.26 | 6.26 | 552.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.4833 | hr | Mus musculus |
| T1/2 | 0.08333 | hr | Homo sapiens |
| T1/2 | 0.08333 | hr | Macaca mulatta |
| T1/2 | 0.08333 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ALK tyrosine kinase receptor | IC50 | = | 15.0 | nM | 7.82 | Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in S... | 22141319 |
| NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) | IC50 | = | 80.0 | nM | 7.1 | Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based... | 22141319 |
| Insulin receptor | IC50 | = | 552.0 | nM | 6.26 | Inhibition of IR | 22141319 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22141319 | 10.1021/jm2010767 | Liver microsomes | 2 |
| 22141319 | 10.1021/jm2010767 | Insulin receptor | 1 |
| 22141319 | 10.1021/jm2010767 | NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) | 1 |
| 22141319 | 10.1021/jm2010767 | ALK tyrosine kinase receptor | 1 |
| 22141319 | 10.1021/jm2010767 | Liver | 1 |
| 22141319 | 10.1021/jm2010767 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine