Compound Detail
CHEMBL2159004
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1c2oc3c(C)c(N)cc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O
Basic Information
| ChEMBL ID | CHEMBL2159004 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YXHLJMWYDTXDHS-IRFLANFNSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1270.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 4.03 | 4.03 | 93000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 93000.0 | nM | 4.03 | Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as sub... | 22695131 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11591511 | 10.1016/s0960-894x(01)00553-4 | Telomerase reverse transcriptase | 3 |
| 22695131 | 10.1016/j.bmcl.2012.05.041 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 722760 | 10.1021/jm00207a021 | P388 | 1 |
| 722760 | 10.1021/jm00207a021 | CCRF-CEM | 1 |
Data from ChEMBL 36 via Core Engine