Assay Detail
Binding
CHEMBL2162206
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Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibition of therapeutically important polymerases with high affinity bis-intercalators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.79 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.70 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 5.52 |
| CHEMBL582355 | — | — | 1 | 4.70 |
| CHEMBL1985453 | ACRIDINE YELLOW | — | 1 | 4.50 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.28 |
| CHEMBL2159004 | — | — | 1 | 4.03 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | - |
| CHEMBL123 | ELLIPTECINE | — | 1 | - |
| CHEMBL81880 | ACRIDINE ORANGE | — | 1 | - |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | - |
| CHEMBL76954 | — | — | 1 | - |
| CHEMBL2159005 | — | — | 1 | - |
| CHEMBL2159006 | — | — | 1 | - |
| CHEMBL2159007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL582355 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1985453 | ACRIDINE YELLOW | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL2159004 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 139000.0 | nM | - |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 182000.0 | nM | - |
| CHEMBL81880 | ACRIDINE ORANGE | IC50 | = | 200000.0 | nM | - |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 270000.0 | nM | - |
| CHEMBL76954 | — | IC50 | - | — | - | |
| CHEMBL2159005 | — | IC50 | - | — | - | |
| CHEMBL2159006 | — | IC50 | - | — | - | |
| CHEMBL2159007 | — | IC50 | - | — | - |