Compound Detail
CHEMBL81880
ACRIDINE ORANGE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL81880 |
| Name | ACRIDINE ORANGE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DPKHZNPWBDQZCN-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
265.4
MW (Da)
3.52
ALogP
3
HBA
0
HBD
19.4
PSA (Ų)
0.66
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 4.91 | 4.91 | 12200.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | IC50 | = | 600.0 | nM | 6.22 | Inhibition of amyloid beta 42 fibril formation by thioflavin T assay | 17270435 |
| Telomerase reverse transcriptase | IC50 | = | 12200.0 | nM | 4.91 | Inhibitory activity against telomerase (Compound released from RNA/DNA heterodup... | 11591511 |
| Telomerase reverse transcriptase | IC50 | = | 12200.0 | nM | 4.91 | Inhibitory activity against telomerase (Compound released from DNA/DNA heterodup... | 11591511 |
| Telomerase reverse transcriptase | IC50 | = | 12200.0 | nM | 4.91 | Inhibitory activity against telomerase (Compound released from underivatized res... | 11591511 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18694955 | 10.1128/aac.00661-08 | NON-PROTEIN TARGET | 7 |
| 18725450 | 10.1128/aac.00245-08 | Pasteurella multocida | 7 |
| 18268083 | 10.1128/aac.01052-07 | NON-PROTEIN TARGET | 6 |
| 7265110 | 10.1021/jm00135a003 | Rattus norvegicus | 5 |
| 18268083 | 10.1128/aac.01052-07 | Escherichia coli | 4 |
| 19770280 | 10.1128/aac.00748-09 | Acinetobacter baumannii | 4 |
| 11591511 | 10.1016/s0960-894x(01)00553-4 | Telomerase reverse transcriptase | 3 |
| 19770280 | 10.1128/aac.00748-09 | Escherichia coli | 3 |
| 17270435 | 10.1016/j.bmcl.2006.10.090 | Amyloid-beta precursor protein | 1 |
| 22695131 | 10.1016/j.bmcl.2012.05.041 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 23122936 | 10.1016/j.bmc.2012.09.068 | Nucleic Acid | 1 |
| 37406384 | 10.1016/j.ejmech.2023.115598 | Calf thymus DNA | 1 |
Data from ChEMBL 36 via Core Engine