Assay Detail
Binding
CHEMBL903491
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Inhibition of amyloid beta 42 fibril formation by thioflavin T assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.99 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245688 | — | — | 1 | 7.00 |
| CHEMBL248132 | — | — | 1 | 6.52 |
| CHEMBL248327 | — | — | 1 | 6.30 |
| CHEMBL247674 | — | — | 1 | 6.30 |
| CHEMBL392878 | — | — | 1 | 6.22 |
| CHEMBL81880 | ACRIDINE ORANGE | — | 1 | 6.22 |
| CHEMBL247930 | — | — | 1 | 6.22 |
| CHEMBL247931 | — | — | 1 | 6.22 |
| CHEMBL247524 | — | — | 1 | 6.16 |
| CHEMBL248131 | — | — | 1 | 6.16 |
| CHEMBL391205 | — | — | 1 | 6.10 |
| CHEMBL247328 | — | — | 1 | 6.10 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 6.10 |
| CHEMBL394713 | — | — | 1 | 6.05 |
| CHEMBL247725 | — | — | 1 | 6.05 |
| CHEMBL247927 | — | — | 1 | 6.05 |
| CHEMBL247932 | — | — | 1 | 6.00 |
| CHEMBL247929 | — | — | 1 | 5.96 |
| CHEMBL248122 | — | — | 1 | 5.96 |
| CHEMBL427878 | — | — | 1 | 5.96 |
| CHEMBL247530 | — | — | 1 | 5.96 |
| CHEMBL248337 | — | — | 1 | 5.96 |
| CHEMBL248133 | — | — | 1 | 5.89 |
| CHEMBL247727 | — | — | 1 | 5.85 |
| CHEMBL247726 | — | — | 1 | 5.77 |
| CHEMBL396917 | — | — | 1 | 5.75 |
| CHEMBL247728 | — | — | 1 | 5.72 |
| CHEMBL427877 | — | — | 1 | 5.64 |
| CHEMBL248338 | — | — | 1 | 5.57 |
| CHEMBL418455 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245688 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL248132 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL248327 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL247674 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL392878 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL81880 | ACRIDINE ORANGE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL247930 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL247931 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL247524 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL248131 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL391205 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL140 | CURCUMIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL247328 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL247927 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL247725 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL394713 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL247932 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL247929 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL248337 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL247530 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL427878 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL248122 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL248133 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL247727 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL247726 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL396917 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL247728 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL427877 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL248338 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL418455 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL245476 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL248339 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL245477 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL245478 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL245479 | — | IC50 | > | 20000.0 | nM | - |