Assay Detail
Binding
CHEMBL816666
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Inhibitory activity against telomerase (Compound released from RNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.04 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.48 |
| CHEMBL94007 | ETHACRIDINE | 2.0 | 1 | 5.09 |
| CHEMBL81880 | ACRIDINE ORANGE | — | 1 | 4.91 |
| CHEMBL329221 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL94007 | ETHACRIDINE | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL81880 | ACRIDINE ORANGE | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL329221 | — | IC50 | = | 21700.0 | nM | 4.66 |