Compound Detail
CHEMBL94007
ETHACRIDINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL94007 |
| Name | ETHACRIDINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | CIKWKGFPFXJVGW-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
4
Known Names
Molecular Properties
253.3
MW (Da)
2.95
ALogP
4
HBA
2
HBD
74.2
PSA (Ų)
0.54
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 4 meas. best 5.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 5.09 | 5.09 | 8200.0 | 3 |
| Bile salt export pump CHEMBL6020 | IC50 | 4.36 | 4.36 | 43480.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 8200.0 | nM | 5.09 | Inhibitory activity against telomerase (Compound released from RNA/DNA heterodup... | 11591511 |
| Telomerase reverse transcriptase | IC50 | = | 8200.0 | nM | 5.09 | Inhibitory activity against telomerase (Compound released from DNA/DNA heterodup... | 11591511 |
| Telomerase reverse transcriptase | IC50 | = | 8200.0 | nM | 5.09 | Inhibitory activity against telomerase (Compound released from underivatized res... | 11591511 |
| Bile salt export pump | IC50 | = | 43480.0 | nM | 4.36 | Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21... | 22961681 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30523084 | 10.1126/science.aat9446 | Plasmodium berghei | 4 |
| 11591511 | 10.1016/s0960-894x(01)00553-4 | Telomerase reverse transcriptase | 3 |
| 30523084 | 10.1126/science.aat9446 | HepG2-CD81 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 28513176 | 10.1021/acs.jmedchem.7b00191 | Unchecked | 1 |
| 22961681 | 10.1124/dmd.112.047068 | Bile salt export pump | 1 |
Data from ChEMBL 36 via Core Engine