Compound Detail
CHEMBL2165336
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CC(C)c1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1
Basic Information
| ChEMBL ID | CHEMBL2165336 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YBMIXYLICGEZNV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
599.5
MW (Da)
4.72
ALogP
8
HBA
2
HBD
128.2
PSA (Ų)
0.22
QED
1
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL252 | IC50 | 8.44 | 8.44 | 3.6 | 1 |
| Endothelin receptor type B CHEMBL1785 | IC50 | 5.61 | 5.61 | 2474.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | IC50 | = | 3.6 | nM | 8.44 | Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells a... | 22862294 |
| Endothelin receptor type B | IC50 | = | 2474.0 | nM | 5.61 | Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells a... | 22862294 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22862294 | 10.1021/jm3009103 | Rattus norvegicus | 2 |
| 22862294 | 10.1021/jm3009103 | Endothelin receptor type B | 1 |
| 22862294 | 10.1021/jm3009103 | Endothelin-1 receptor | 1 |
Data from ChEMBL 36 via Core Engine