Compound Detail
CHEMBL2170969
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2170969 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ROCGAPPSZYVLBK-JTQLQIEISA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
357.8
MW (Da)
2.93
ALogP
4
HBA
3
HBD
90.8
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.15
Ki 1 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 8.89 | 8.89 | 1.3 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | Ki | = | 1.3 | nM | 8.89 | Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to... | 22924734 |
| Hepatocyte growth factor receptor | IC50 | = | 7.0 | nM | 8.15 | Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition... | 22924734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22924734 | 10.1021/jm300967g | Hepatocyte growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine