Compound Detail
CHEMBL217416
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL217416 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QTOFQNRPGVRDSV-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
1
PK Parameters
2
Publications
0
Known Names
Molecular Properties
450.9
MW (Da)
4.57
ALogP
7
HBA
4
HBD
113.0
PSA (Ų)
0.31
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.46
IC50 1 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase 1 CHEMBL3587 | IC50 | 6.55 | 6.55 | 280.0 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 CHEMBL3587 | EC50 | 6.46 | 6.46 | 350.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | - | - | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | = | 280.0 | nM | 6.55 | Inhibition of MEK-1 activity | 16934458 |
| Dual specificity mitogen-activated protein kinase kinase 1 | EC50 | = | 350.0 | nM | 6.46 | Inhibitory activity against MEK-1 | 16934458 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16934458 | 10.1016/j.bmcl.2006.08.048 | Dual specificity mitogen-activated protein kinase kinase 1 | 2 |
| 16934458 | 10.1016/j.bmcl.2006.08.048 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine