Compound Detail
CHEMBL217754
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Basic Information
| ChEMBL ID | CHEMBL217754 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RORVKNCKCFHQRE-QMMMGPOBSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
228.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase CHEMBL3202 | Ki | 7.28 | 7.28 | 53.0 | 1 |
| Prolyl endopeptidase FAP CHEMBL4683 | Ki | 6.79 | 6.79 | 161.0 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | Ki | 5.34 | 5.34 | 4600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase | Ki | = | 53.0 | nM | 7.28 | Inhibitory constant against POP | 17174090 |
| Prolyl endopeptidase FAP | Ki | = | 161.0 | nM | 6.79 | Inhibitory constant against FAP | 17174090 |
| Dipeptidyl peptidase 4 | Ki | = | 4600.0 | nM | 5.34 | Inhibition constant against DPP-4 | 17174090 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17174090 | 10.1016/j.bmcl.2006.11.072 | Dipeptidyl peptidase 4 | 1 |
| 17174090 | 10.1016/j.bmcl.2006.11.072 | Prolyl endopeptidase | 1 |
| 17174090 | 10.1016/j.bmcl.2006.11.072 | Prolyl endopeptidase FAP | 1 |
Data from ChEMBL 36 via Core Engine