Compound Detail
CHEMBL2178395
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Basic Information
| ChEMBL ID | CHEMBL2178395 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZAGYRNAJGXPODJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
360.5
MW (Da)
2.33
ALogP
8
HBA
2
HBD
106.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutaminase kidney isoform, mitochondrial CHEMBL2146302 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutaminase kidney isoform, mitochondrial | IC50 | = | 15000.0 | nM | 4.82 | Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as su... | 23151085 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23151085 | 10.1021/jm301191p | Glutaminase kidney isoform, mitochondrial | 1 |
Data from ChEMBL 36 via Core Engine