Compound Detail
CHEMBL2203559
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Basic Information
| ChEMBL ID | CHEMBL2203559 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VGNSQEJXQARLLC-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
368.4
MW (Da)
2.48
ALogP
5
HBA
2
HBD
89.1
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Casein kinase I isoform gamma-2 CHEMBL2543 | IC50 | 7.62 | 7.62 | 24.0 | 1 |
| Casein kinase I isoform delta CHEMBL2828 | IC50 | 7.24 | 7.24 | 58.0 | 1 |
| Casein kinase I isoform alpha CHEMBL2793 | IC50 | 6.84 | 6.84 | 146.0 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 5.95 | 5.95 | 1120.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Casein kinase I isoform gamma-2 | IC50 | = | 24.0 | nM | 7.62 | Inhibition of CK1-gamma 2 using biotin[long chain]-KKRRRAL{pS}VATLPGL substrate ... | 24900428 |
| Casein kinase I isoform delta | IC50 | = | 58.0 | nM | 7.24 | Inhibition of CK1-delta using biotin[long chain]-KKRRRAL{pS}VATLPGL substrate in... | 24900428 |
| Casein kinase I isoform alpha | IC50 | = | 146.0 | nM | 6.84 | Inhibition of CK1-alpha using biotin[long chain]-KKRRRAL{pS}VATLPGL substrate in... | 24900428 |
| Glycogen synthase kinase-3 beta | IC50 | = | 1120.0 | nM | 5.95 | Inhibition of GSK3beta | 24900428 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900428 | 10.1021/ml300278f | Unchecked | 1 |
| 24900428 | 10.1021/ml300278f | Glycogen synthase kinase-3 beta | 1 |
| 24900428 | 10.1021/ml300278f | Casein kinase I isoform delta | 1 |
| 24900428 | 10.1021/ml300278f | Casein kinase I isoform alpha | 1 |
| 24900428 | 10.1021/ml300278f | Casein kinase I isoform gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine