Compound Detail
CHEMBL2205321
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Basic Information
| ChEMBL ID | CHEMBL2205321 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VEFWRMMQEHDNJT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
380.5
MW (Da)
5.77
ALogP
2
HBA
0
HBD
27.0
PSA (Ų)
0.54
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 CHEMBL4633 | IC50 | 5.58 | 5.58 | 2610.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 | IC50 | = | 2610.0 | nM | 5.58 | Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step p... | 23084278 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23084278 | 10.1016/j.bmcl.2012.09.080 | Potassium voltage-gated channel subfamily A member 3 | 1 |
Data from ChEMBL 36 via Core Engine