Compound Detail
CHEMBL220775
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Basic Information
| ChEMBL ID | CHEMBL220775 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XCBFDMFJYYJHAL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
320.4
MW (Da)
4.33
ALogP
2
HBA
2
HBD
39.3
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL311 | IC50 | 5.94 | 5.94 | 1158.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B | IC50 | = | 1158.0 | nM | 5.94 | Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assess... | 17290978 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17290978 | 10.1021/jm060420k | Glutamate receptor ionotropic, NMDA 2B | 2 |
Data from ChEMBL 36 via Core Engine