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Compound Detail

CHEMBL2228072

6-Cl-4-Pr-D-DIBOA
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CCCON1C(=O)COc2ccc(Cl)cc21

Basic Information

ChEMBL ID CHEMBL2228072
Name 6-Cl-4-Pr-D-DIBOA
Phase Preclinical
Structure Type MOL
InChI Key HMODJBIEYMVWPN-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

241.7
MW (Da)
2.41
ALogP
3
HBA
0
HBD
38.8
PSA (Ų)
0.82
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H12ClNO3
MW 241.67
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness -0.87

Activity Summary

IC50 2 meas. best 7.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Lepidium sativum
CHEMBL612381
IC50 7.22 7.22 60.0 1
Allium cepa
CHEMBL613790
IC50 6.7 6.7 200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20014762 10.1021/jf903445m Allium cepa 4
20014762 10.1021/jf903445m Lepidium sativum 3
20014762 10.1021/jf903445m Lactuca sativa 3
20014762 10.1021/jf903445m Solanum lycopersicum 3

Data from ChEMBL 36 via Core Engine