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Compound Detail

CHEMBL2251446

PROTHIOCONAZOLE
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OC(Cc1ccccc1Cl)(Cn1nc[nH]c1=S)C1(Cl)CC1

Basic Information

ChEMBL ID CHEMBL2251446
Name PROTHIOCONAZOLE
Phase Preclinical
Structure Type MOL
InChI Key MNHVNIJQQRJYDH-UHFFFAOYSA-N
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

344.3
MW (Da)
3.34
ALogP
4
HBA
2
HBD
53.8
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C14H15Cl2N3OS
MW 344.27
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -0.90

Activity Summary

EC50 5 meas. best 4.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fusarium graminearum
CHEMBL2366834
EC50 4.5 4.5 32000.0 5

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23073993 10.1002/ps.3408 Oculimacula yallundae 18
- 10.1016/j.cropro.2006.06.006 Fusarium graminearum 5
- 10.1016/j.cropro.2006.06.006 Rattus norvegicus 2
23073993 10.1002/ps.3408 Unchecked 2
23073993 10.1002/ps.3408 Oculimacula acuformis 2
30108980 10.1039/C8MD00155C Fusarium graminearum 2
- 10.1016/j.cropro.2006.06.006 NON-PROTEIN TARGET 1

Data from ChEMBL 36 via Core Engine