Compound Detail
CHEMBL22608
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Basic Information
| ChEMBL ID | CHEMBL22608 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZQIVPRINVRSPLR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
196.6
MW (Da)
1.69
ALogP
4
HBA
2
HBD
66.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.25 | 4.25 | 56300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 56300.0 | nM | 4.25 | Inhibition of [3H]glycine binding to glycine site of N-methyl-D-aspartate glutam... | 1826744 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8917657 | 10.1021/jm960520y | Glutamate NMDA receptor | 2 |
| 1826744 | 10.1021/jm00108a002 | Glutamate NMDA receptor | 2 |
| 8765507 | 10.1021/jm960214k | Glutamate receptor ionotropic, NMDA 1 | 2 |
| 1826744 | 10.1021/jm00108a002 | Glutamate receptor ionotropic, AMPA | 1 |
| 1826744 | 10.1021/jm00108a002 | Glutamate receptor ionotropic, kainate | 1 |
Data from ChEMBL 36 via Core Engine