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Compound Detail

CHEMBL2262220

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C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1.[I-]

Basic Information

ChEMBL ID CHEMBL2262220
Phase Preclinical
Structure Type MOL
InChI Key QQVODEDJDRXHCO-MKSBGGEFSA-M
Parent Compound CHEMBL3139826
Active Moiety CHEMBL3139826
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

312.4
MW (Da)
3.27
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H26INO2
MW 439.34
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.55

Activity Summary

Kd 3 meas. best 8.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 8.14 8.14 7.2 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 7.46 7.46 34.7 1
Muscarinic receptor 2
CHEMBL1075061
Kd 7.24 7.24 57.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-006-0143-5 Unchecked 4
- 10.1007/s00044-006-0143-5 Muscarinic acetylcholine receptor M3 1
- 10.1007/s00044-006-0143-5 Muscarinic receptor 2 1

Data from ChEMBL 36 via Core Engine