Compound Detail
CHEMBL2272690
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Basic Information
| ChEMBL ID | CHEMBL2272690 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GWNHITXDNISDIP-LFIBNONCSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
277.7
MW (Da)
0.89
ALogP
4
HBA
0
HBD
72.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinic acetylcholine receptor alpha 5 subunit CHEMBL2366408 | Ki | 8.22 | 8.22 | 6.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotinic acetylcholine receptor alpha 5 subunit | Ki | = | 6.0 | nM | 8.22 | Displacement of [3H]imidacloprid from nicotinic acetylcholine receptor in Musca ... | 12720388 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12720388 | 10.1021/jf021185r | Aphis gossypii | 3 |
| 12720388 | 10.1021/jf021185r | Nephotettix cincticeps | 1 |
| 12720388 | 10.1021/jf021185r | Nilaparvata lugens | 1 |
| 12720388 | 10.1021/jf021185r | Bemisia tabaci | 1 |
| 12720388 | 10.1021/jf021185r | Nicotinic acetylcholine receptor alpha 5 subunit | 1 |
Data from ChEMBL 36 via Core Engine