Compound Detail
CHEMBL2283098
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Basic Information
| ChEMBL ID | CHEMBL2283098 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QKMOTFACRGIKHM-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3138790 |
| Active Moiety | CHEMBL3138790 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
319.5
MW (Da)
2.59
ALogP
4
HBA
1
HBD
41.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL5076 | Kd | 6.72 | 6.72 | 190.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Kd | = | 190.55 | nM | 6.72 | Antagonist activity at histamine H3 receptor in Cavia porcellus (guinea pig) ile... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-012-0090-2 | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine