Compound Detail
CHEMBL229284
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Cc1cn([C@H]2CC[C@@H](OCP(=O)(O)O)O2)c(=O)[nH]c1=O.O=P(O)(O)OP(=O)(O)O
Basic Information
| ChEMBL ID | CHEMBL229284 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YJNVRDXTKUQTMR-WLYNEOFISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
484.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.27 | 5.27 | 5400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 5400.0 | nM | 5.27 | Inhibition of HIV1 reverse transcriptase | 17562366 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17562366 | 10.1016/j.bmc.2007.05.047 | Human immunodeficiency virus 1 | 1 |
| 17562366 | 10.1016/j.bmc.2007.05.047 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 17562366 | 10.1016/j.bmc.2007.05.047 | MT2 | 1 |
Data from ChEMBL 36 via Core Engine