Assay Detail
Binding
CHEMBL906565
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Inhibition of HIV1 reverse transcriptase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.30 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.22 |
| CHEMBL444314 | — | — | 1 | 6.92 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.42 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.41 |
| CHEMBL122885 | — | — | 1 | 6.41 |
| CHEMBL229284 | — | — | 1 | 5.27 |
| CHEMBL229111 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL991 | STAVUDINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL444314 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL122885 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL229284 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL229111 | — | IC50 | = | 5400.0 | nM | 5.27 |