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Compound Detail

CHEMBL2297279

KAEMPFEROL 3-O-D-GALACTOSIDE
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O=c1c(OC2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12

Basic Information

ChEMBL ID CHEMBL2297279
Name KAEMPFEROL 3-O-D-GALACTOSIDE
Phase Preclinical
Structure Type MOL
InChI Key JPUKWEQWGBDDQB-HBDJNLTOSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

448.4
MW (Da)
-0.24
ALogP
11
HBA
7
HBD
190.3
PSA (Ų)
0.28
QED
2
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C21H20O11
MW 448.38
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness 2.07

Activity Summary

IC50 1 meas. best 7.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL220
IC50 7.92 7.92 12.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Acetylcholinesterase IC50 = 12.0 nM 7.92 Inhibition of AChE (unknown origin) -

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-012-0353-y Acetylcholinesterase 1

Data from ChEMBL 36 via Core Engine