Compound Detail
CHEMBL23022
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Basic Information
| ChEMBL ID | CHEMBL23022 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NLZAWUVAIXEENQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
273.3
MW (Da)
2.65
ALogP
4
HBA
0
HBD
40.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 CHEMBL4818 | IC50 | 4.75 | 4.75 | 18000.0 | 1 |
| N1E-115 CHEMBL612553 | IC50 | 4.38 | 4.38 | 42000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 | IC50 | = | 18000.0 | nM | 4.75 | Inhibition of voltage-gated potassium channel subunit Kv1.3 expressed in L929 ce... | 11312924 |
| N1E-115 | IC50 | = | 42000.0 | nM | 4.38 | Inhibition of N1E-115 cells Kv channels | 11312924 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11312924 | 10.1021/jm001007u | N1E-115 | 5 |
| 11312924 | 10.1021/jm001007u | Potassium voltage-gated channel subfamily A member 3 | 4 |
Data from ChEMBL 36 via Core Engine