Compound Detail
CHEMBL2312401
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Basic Information
| ChEMBL ID | CHEMBL2312401 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZVLQXZKBRAEEDB-SFYZADRCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
290.3
MW (Da)
0.12
ALogP
5
HBA
4
HBD
138.9
PSA (Ų)
0.47
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 CHEMBL2919 | Ki | 5.5 | 5.5 | 3180.0 | 1 |
| Glutamate receptor ionotropic, kainate 3 CHEMBL3744 | Ki | 4.35 | 4.35 | 44500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 | Ki | = | 3180.0 | nM | 5.5 | Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant ... | 23414088 |
| Glutamate receptor ionotropic, kainate 3 | Ki | = | 44500.0 | nM | 4.35 | Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant ... | 23414088 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23414088 | 10.1021/jm301433m | Unchecked | 2 |
| 23414088 | 10.1021/jm301433m | Glutamate receptor ionotropic, kainate 3 | 1 |
| 23414088 | 10.1021/jm301433m | Glutamate receptor ionotropic, kainate 2 | 1 |
| 23414088 | 10.1021/jm301433m | Glutamate receptor ionotropic, kainate 1 | 1 |
| 23414088 | 10.1021/jm301433m | Glutamate receptor 2 | 1 |
| 23414088 | 10.1021/jm301433m | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine