Glutamate receptor ionotropic, kainate 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P22756. Use UniProt P22756 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22756 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, kainate 1
Review this target as Glutamate receptor ionotropic, kainate 1, mapped to UniProt P22756. Sequence length is 949 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor ionotropic, kainate 1 as ChEMBL target CHEMBL2919, mapped to UniProt P22756. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutamate receptor ionotropic, kainate 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P22756 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, kainate 1 |
| UniProt Accession | P22756 |
| Component Type | Protein |
| Sequence Length | 949 aa |
Glutamate receptor ionotropic, kainate 1
Review this target as Glutamate receptor ionotropic, kainate 1, mapped to UniProt P22756. Sequence length is 949 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL370038 | 10.09 | Ki | 0.081 | Preclinical |
| CHEMBL2178920 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL2178919 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL288166 | 9.18 | Ki | 0.6607 | Preclinical |
| CHEMBL482097 | 8.97 | Ki | 1.072 | Preclinical |
| CHEMBL13378 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL27130 | 8.67 | Ki | 2.13 | Preclinical |
| CHEMBL121915 | 8.62 | Ki | 2.4 | Preclinical |
| CHEMBL28472 | 8.59 | Ki | 2.57 | Preclinical |
| CHEMBL370941 | 8.54 | Ki | 2.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 19 | 90 | 5.9 |
| single protein format | 14 | 16 | 6.7 |
| assay format | 3 | 8 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 10 | 7.1 |
| tissue-based format | 4 | 4 | 5.4 |
| assay format | 3 | 22 | 6.3 |