Review anchor
Glutamate receptor ionotropic, kainate 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Glutamate receptor ionotropic, kainate 1
CHEMBL2919
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor ionotropic, kainate 1 as ChEMBL target CHEMBL2919, mapped to UniProt P22756. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2919
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P22756
Glutamate receptor ionotropic, kainate 1
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Glutamate receptor ionotropic, kainate 1 matters
Glutamate receptor ionotropic, kainate 1 is reviewed as Glutamate receptor ionotropic, kainate 1 (UniProt P22756); the current evidence base includes 0 approved drugs, 252 compounds, and 49 assays, with lead potency reaching pChEMBL 10.1.
Protein context
Glutamate receptor ionotropic, kainate 1
Glutamate receptor ionotropic, kainate 1 Sequence length is 949 aa.
Review this target as Glutamate receptor ionotropic, kainate 1, mapped to UniProt P22756. Sequence length is 949 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P22756
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 0 approved drugs, 252 compounds, and 49 assays for this target. The dominant activity type is KI. CHEMBL370038 is the current potency anchor at pChEMBL 10.1.
Use CHEMBL370038 as the tractability anchor when discussing potency (pChEMBL 10.1).
Activity source · ChEMBL 36 via Core Engine
pChEMBL 10.1
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Glutamate receptor ionotropic, kainate 1 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P22756, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
252
Total Compounds
49
Total Assays
0
Approved Drugs
IC50: 21.0, KI: 219.0, EC50: 22.0, KD: 33.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL370038
|
10.1 | Ki | — |
|
|
No preferred name
CHEMBL2178920
|
9.7 | IC50 | — |
|
|
No preferred name
CHEMBL2178919
|
9.6 | IC50 | — |
|
|
No preferred name
CHEMBL288166
|
9.2 | Ki | — |
|
|
No preferred name
CHEMBL482097
|
9.0 | Ki | — |
Source Header