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Compound Detail

CHEMBL2326322

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Oc1ccc2sc(CNc3nncc(-c4c(O)ccc5ccccc45)n3)nc2c1

Basic Information

ChEMBL ID CHEMBL2326322
Phase Preclinical
Structure Type MOL
InChI Key OMYVIAHKCNOLKD-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

401.4
MW (Da)
4.32
ALogP
8
HBA
3
HBD
104.0
PSA (Ų)
0.41
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H15N5O2S
MW 401.45
Aromatic Rings 5
Heavy Atoms 29
NP-Likeness -1.12

Activity Summary

IC50 4 meas. best 7.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 7.7 6.9933 20.0 3
Klebsiella pneumoniae
CHEMBL350
IC50 7.07 7.07 85.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23409840 10.1021/jm301499r Escherichia coli 4
23409840 10.1021/jm301499r Unchecked 4
23409840 10.1021/jm301499r Klebsiella pneumoniae 1
23409840 10.1021/jm301499r HepG2 1

Data from ChEMBL 36 via Core Engine