Assay Detail
Binding
CHEMBL2329778
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Inhibition of Klebsiella pneumoniae ATCC 700603 hldE-K expressed in Escherichia coli BL21 using beta-heptose 7-phosphate as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by luminescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Klebsiella pneumoniae |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.58 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326322 | — | — | 1 | 7.07 |
| CHEMBL2312560 | — | — | 1 | 7.00 |
| CHEMBL2325142 | — | — | 1 | 6.82 |
| CHEMBL2325154 | — | — | 1 | 6.37 |
| CHEMBL2326324 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326322 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2312560 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2325142 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2325154 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2326324 | — | IC50 | = | 2300.0 | nM | 5.64 |