Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL2326324

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccc2sc(CNc3nncc(-c4c(Cl)cccc4Cl)n3)nc2c1

Basic Information

ChEMBL ID CHEMBL2326324
Phase Preclinical
Structure Type MOL
InChI Key QXYYGNCFVRQOCX-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

418.3
MW (Da)
5.08
ALogP
7
HBA
1
HBD
72.8
PSA (Ų)
0.49
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H13Cl2N5OS
MW 418.31
Aromatic Rings 4
Heavy Atoms 27
NP-Likeness -1.90

Activity Summary

IC50 4 meas. best 6.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 6.89 5.9 130.0 3
Klebsiella pneumoniae
CHEMBL350
IC50 5.64 5.64 2300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23409840 10.1021/jm301499r Unchecked 4
23409840 10.1021/jm301499r Escherichia coli 4
23409840 10.1021/jm301499r Klebsiella pneumoniae 1

Data from ChEMBL 36 via Core Engine