Compound Detail
CHEMBL2332622
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Basic Information
| ChEMBL ID | CHEMBL2332622 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DDSNGWWAXQJNCU-ZBFHGGJFSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
355.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 7.19 | 7.19 | 65.0 | 1 |
| Prolyl endopeptidase CHEMBL3202 | IC50 | 7.02 | 7.02 | 96.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase FAP | IC50 | = | 65.0 | nM | 7.19 | Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 min... | 23594271 |
| Prolyl endopeptidase | IC50 | = | 96.0 | nM | 7.02 | Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mi... | 23594271 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23594271 | 10.1021/jm400351a | Prolyl endopeptidase | 1 |
| 23594271 | 10.1021/jm400351a | Prolyl endopeptidase FAP | 1 |
| 23594271 | 10.1021/jm400351a | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine