Compound Detail
CHEMBL2332856
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Basic Information
| ChEMBL ID | CHEMBL2332856 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIGIEHDTVCPMDK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
399.3
MW (Da)
4.42
ALogP
5
HBA
2
HBD
92.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.15 | 5.15 | 7070.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 7070.0 | nM | 5.15 | Inhibition of FLT3-ITD mutant in human MV4-11 cells assessed as decrease in cell... | 23362959 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23362959 | 10.1021/jm301537p | Vascular endothelial growth factor receptor 2 | 1 |
| 23362959 | 10.1021/jm301537p | HeLa | 1 |
| 23362959 | 10.1021/jm301537p | Receptor-type tyrosine-protein kinase FLT3 | 1 |
Data from ChEMBL 36 via Core Engine