Compound Detail
CHEMBL2333204
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Basic Information
| ChEMBL ID | CHEMBL2333204 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NVDCBEGCEURYOV-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
350.4
MW (Da)
3.85
ALogP
4
HBA
0
HBD
51.1
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 4.26 | 4.26 | 54900.0 | 2 |
| B16-F10 CHEMBL612656 | IC50 | 4.05 | 4.05 | 89710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 54900.0 | nM | 4.26 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 23312949 |
| Telomerase reverse transcriptase | IC50 | = | 54954.09 | nM | 4.26 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 23312949 |
| B16-F10 | IC50 | = | 89710.0 | nM | 4.05 | Anticancer activity against mouse B16F10 cells assessed as cell survival measure... | 23312949 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23312949 | 10.1016/j.bmcl.2012.12.010 | Telomerase reverse transcriptase | 2 |
| 23312949 | 10.1016/j.bmcl.2012.12.010 | B16-F10 | 1 |
Data from ChEMBL 36 via Core Engine