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Assay Detail

CHEMBL2344662

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of telomerase in human SGC7901 cells by TRAP assay
43
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type SGC-7901
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Telomerase reverse transcriptase (CHEMBL2916)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors.
Luo Y, Zhang S, Qiu KM, Liu ZJ, Yang YS, Fu J, Zhong WQ, Zhu HL.
Bioorg Med Chem Lett (2013) 23 : 1091 -1095
PubMed 23312949 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 4.78 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2333209 2 6.05
CHEMBL1487360 2 5.89
CHEMBL284328 HOMIDIUM BROMIDE 2.0 1 5.58
CHEMBL1542147 2 5.47
CHEMBL1684641 2 5.21
CHEMBL2333208 2 5.17
CHEMBL2333207 2 5.14
CHEMBL2333210 2 5.06
CHEMBL2333216 2 4.97
CHEMBL2333215 2 4.87
CHEMBL2333211 2 4.73
CHEMBL2333214 2 4.64
CHEMBL2333213 2 4.62
CHEMBL2333212 2 4.59
CHEMBL2333217 2 4.43
CHEMBL2333205 2 4.33
CHEMBL2333204 2 4.26
CHEMBL2333218 2 4.17
CHEMBL2333203 2 4.12
CHEMBL2333202 2 4.08
CHEMBL2333201 2 4.08
CHEMBL2333206 2 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2333209 IC50 = 899.5 nM 6.05
CHEMBL2333209 IC50 = 900.0 nM 6.05
CHEMBL1487360 IC50 = 1300.17 nM 5.89
CHEMBL1487360 IC50 = 1300.0 nM 5.89
CHEMBL284328 HOMIDIUM BROMIDE IC50 = 2600.0 nM 5.58
CHEMBL1542147 IC50 = 3400.0 nM 5.47
CHEMBL1542147 IC50 = 3396.25 nM 5.47
CHEMBL1684641 IC50 = 6194.41 nM 5.21
CHEMBL1684641 IC50 = 6200.0 nM 5.21
CHEMBL2333208 IC50 = 6700.0 nM 5.17
CHEMBL2333208 IC50 = 6698.85 nM 5.17
CHEMBL2333207 IC50 = 7294.58 nM 5.14
CHEMBL2333207 IC50 = 7300.0 nM 5.14
CHEMBL2333210 IC50 = 8700.0 nM 5.06
CHEMBL2333210 IC50 = 8709.64 nM 5.06
CHEMBL2333216 IC50 = 10600.0 nM 4.97
CHEMBL2333216 IC50 = 10592.54 nM 4.97
CHEMBL2333215 IC50 = 13400.0 nM 4.87
CHEMBL2333215 IC50 = 13396.77 nM 4.87
CHEMBL2333211 IC50 = 18500.0 nM 4.73
CHEMBL2333211 IC50 = 18492.69 nM 4.73
CHEMBL2333214 IC50 = 22900.0 nM 4.64
CHEMBL2333214 IC50 = 22908.68 nM 4.64
CHEMBL2333213 IC50 = 23800.0 nM 4.62
CHEMBL2333213 IC50 = 23823.19 nM 4.62
CHEMBL2333212 IC50 = 25700.0 nM 4.59
CHEMBL2333212 IC50 = 25703.96 nM 4.59
CHEMBL2333217 IC50 = 37400.0 nM 4.43
CHEMBL2333217 IC50 = 37411.06 nM 4.43
CHEMBL2333205 IC50 = 46700.0 nM 4.33
CHEMBL2333205 IC50 = 46665.94 nM 4.33
CHEMBL2333204 IC50 = 54954.09 nM 4.26
CHEMBL2333204 IC50 = 54900.0 nM 4.26
CHEMBL2333218 IC50 = 68233.87 nM 4.17
CHEMBL2333218 IC50 = 68300.0 nM 4.17
CHEMBL2333203 IC50 = 76383.58 nM 4.12
CHEMBL2333203 IC50 = 76400.0 nM 4.12
CHEMBL2333202 IC50 = 82603.79 nM 4.08
CHEMBL2333201 IC50 = 83560.3 nM 4.08
CHEMBL2333202 IC50 = 82600.0 nM 4.08
CHEMBL2333201 IC50 = 83600.0 nM 4.08
CHEMBL2333206 IC50 = 93200.0 nM 4.03
CHEMBL2333206 IC50 = 93110.79 nM 4.03