Compound Detail
CHEMBL2333206
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Basic Information
| ChEMBL ID | CHEMBL2333206 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PJGOWJKDDHTROO-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
381.4
MW (Da)
3.45
ALogP
6
HBA
0
HBD
94.3
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 4.03 | 4.03 | 93110.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 93200.0 | nM | 4.03 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 23312949 |
| Telomerase reverse transcriptase | IC50 | = | 93110.79 | nM | 4.03 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 23312949 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23312949 | 10.1016/j.bmcl.2012.12.010 | Telomerase reverse transcriptase | 2 |
Data from ChEMBL 36 via Core Engine