Compound Detail
CHEMBL233626
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Basic Information
| ChEMBL ID | CHEMBL233626 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FLIDDGXWDFUXDF-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
312.2
MW (Da)
2.53
ALogP
4
HBA
2
HBD
77.1
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase; MEK1/2 CHEMBL2111289 | IC50 | 5.41 | 5.325 | 3900.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | IC50 | = | 3900.0 | nM | 5.41 | Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ER... | 17880056 |
| Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | IC50 | = | 5720.0 | nM | 5.24 | Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK c... | 17880056 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17880056 | 10.1021/jm0704548 | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | 2 |
Data from ChEMBL 36 via Core Engine