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Compound Detail

CHEMBL2336751

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COc1cc([C@H]2Oc3c(OC)cc(CCCO)cc3[C@@H]2CO)ccc1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Basic Information

ChEMBL ID CHEMBL2336751
Phase Preclinical
Structure Type MOL
InChI Key NYAPVWGUAUDHRY-KUCLMONLSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

522.5
MW (Da)
0.02
ALogP
11
HBA
6
HBD
167.5
PSA (Ų)
0.25
QED
3
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H34O11
MW 522.55
Aromatic Rings 2
Heavy Atoms 37
NP-Likeness 1.88

Activity Summary

IC50 1 meas. best 5.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Histone deacetylase 1
CHEMBL325
IC50 5.44 5.44 3600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Histone deacetylase 1 IC50 = 3600.0 nM 5.44 Inhibition of HDAC1 (unknown origin) using H3(1 to 21)K9 after 60 mins by fluore... 28541690

Literature References

Data from ChEMBL 36 via Core Engine