Compound Detail
CHEMBL2337364
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2337364 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AWTDSPKSEWBWCH-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
362.2
MW (Da)
4.88
ALogP
4
HBA
3
HBD
79.6
PSA (Ų)
0.47
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 4.41 | 4.41 | 38900.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 4.41 | 4.41 | 38900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 38900.0 | nM | 4.41 | Inhibition of EGFR in human A431 cells assessed as inhibition of EGF-induced tyr... | 23434139 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 38900.0 | nM | 4.41 | Inhibition of VEGFR2 in human U251 cells assessed as inhibition of VEGF-induced ... | 23434139 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23434139 | 10.1016/j.bmc.2013.01.040 | A-431 | 1 |
| 23434139 | 10.1016/j.bmc.2013.01.040 | Platelet-derived growth factor receptor beta | 1 |
| 23434139 | 10.1016/j.bmc.2013.01.040 | Epidermal growth factor receptor | 1 |
| 23434139 | 10.1016/j.bmc.2013.01.040 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine