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Compound Detail

CHEMBL2337510

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C[C@@H]1N(c2ccc(C#N)c(Cl)c2)CC[C@@]1(O)c1ccc(C(N)=O)cc1

Basic Information

ChEMBL ID CHEMBL2337510
Phase Preclinical
Structure Type MOL
InChI Key CONUXBCBVUEWCE-BUXKBTBVSA-N
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

355.8
MW (Da)
2.80
ALogP
4
HBA
2
HBD
90.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H18ClN3O2
MW 355.83
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.90

Activity Summary

IC50 4 meas. best 8.05
EC50 1 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
IC50 8.05 7.6925 9.0 4
Androgen receptor
CHEMBL1871
EC50 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23199477 10.1016/j.bmc.2012.11.001 Androgen receptor 6

Data from ChEMBL 36 via Core Engine