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Compound Detail

CHEMBL2337512

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CNC(=O)c1ccc([C@]2(O)CCN(c3ccc(C#N)c(Cl)c3)[C@H]2C)nc1

Basic Information

ChEMBL ID CHEMBL2337512
Phase Preclinical
Structure Type MOL
InChI Key UAOZWGPKKJVBSQ-BUXKBTBVSA-N
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

370.8
MW (Da)
2.45
ALogP
5
HBA
2
HBD
89.2
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H19ClN4O2
MW 370.84
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.24

Activity Summary

IC50 4 meas. best 7.8
EC50 1 meas. best 5.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
IC50 7.8 7.2225 16.0 4
Androgen receptor
CHEMBL1871
EC50 5.29 5.29 5100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23199477 10.1016/j.bmc.2012.11.001 Androgen receptor 6

Data from ChEMBL 36 via Core Engine