Compound Detail
CHEMBL2337518
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2337518 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WLYBSAPGUZCDGP-DJJJIMSYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
1.80
ALogP
5
HBA
2
HBD
89.2
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Androgen receptor CHEMBL1871 | IC50 | 6.4 | 5.6625 | 400.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Androgen receptor | IC50 | = | 400.0 | nM | 6.4 | Antagonist activity at wild type Androgen receptor (unknown origin) expressed in... | 23199477 |
| Androgen receptor | IC50 | = | 1400.0 | nM | 5.85 | Antagonist activity at Androgen receptor T877A mutant (unknown origin) expressed... | 23199477 |
| Androgen receptor | IC50 | = | 5300.0 | nM | 5.28 | Inhibition of Androgen receptor T877A mutant (unknown origin) expressed in Frees... | 23199477 |
| Androgen receptor | IC50 | = | 7600.0 | nM | 5.12 | Inhibition of wild type Androgen receptor (unknown origin) expressed in Freestyl... | 23199477 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23199477 | 10.1016/j.bmc.2012.11.001 | Androgen receptor | 6 |
Data from ChEMBL 36 via Core Engine